Lovastatin induces VSMC differentiation through inhibition of Rheb and mTOR
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چکیده
منابع مشابه
Lovastatin induces VSMC differentiation through inhibition of Rheb and mTOR.
It is becoming increasingly clear that cholesterol-independent effects of statins also contribute to the cardioprotective effects, but these mechanisms remain poorly understood. We investigated the effects of lovastatin on vascular smooth muscle phenotype. We have previously shown that mammalian target of rapamycin complex 1 (mTORC1) inhibition with rapamycin induces vascular smooth muscle cell...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Cell Physiology
سال: 2010
ISSN: 0363-6143,1522-1563
DOI: 10.1152/ajpcell.00429.2009